ChBE 481/581 Biochemical Engineering (Spring 2008)

Call Number: 01434/01444  (ChE481/581)
Time: MWF 10:10-11:00 a.m.
Classroom: MWF Stocker 190
Instructor: Tingyue Gu  (gu@ohio.edu)
Office: Stocker 178, Office Phone: 593-1499
Office Hours: 11:00 a.m. -12:00 p.m. and other times when I am available in my office

Homework Assignments and Handouts are here.  Some handouts are posted on the Blackboard server for password-protected access. A sample midterm exam and a PDF file for all the transparencies shown in class will be e-mailed to you or made available on the Blackboard server.

Final Grade
For undergrads:  20% homework, 15% lab project, 5% short term paper on bioenergy or biorefinery, 30% midterm, 30% final exam.
For grads:  20% homework, 10% lab project, 10% in-depth term paper, 30% midterm, 30% final exam.
Exams are closed-book. Grades are posted on Blackboard.

Required Textbook
Bioprocess Engineering by Michael L. Shuler/Fikret Kargi, Prentice Hall, Englewood Cliffs, 2nd Edition, 2002. (If you have the 1st edition, use it. You may also share a textbook among your classmates. It is easy to borrow the textbook from OhioLink.)

Reference Books
1. Biochemistry by J. M. Berg et al., 6th Edition, W. H. Freeman & Co., San Francisco, 2006.
2. James E. Bailey and David F. Ollis, Biochemical Engineering Fundamentals, McGraw Hill, New York, 1986.
3.  Harvey W. Blanch and Douglas S. Clark, Biochemical Engineering, Marcel Dekker, New York, 1996.
4.  Raul J. Cano and Jaime S. Colome, Microbiology, West Publishing Co., St. Paul, 1986 (or other similar and newer books).

Brief Syllabus
1.  Basics of biology (4 classes)
2.  Enzyme kinetics (4 classes)
3.  Genetics and cell metabolism (3 classes)
4. Major metabolic pathways (3 classes)
5. Cell growth kinetics (3 classes)
6. Stoichiometry of cell growth and production formation (1 class). Start lab experiments.
7. Recombinant DNA technology (2 classes)
8. Batch culture and chemostat (4 classes)
9. Reactor control and scale-up. (1 class)
10.  Sterilization (1 class)
11. Introduction to bioseparations (1 class)

Guidelines for homework and term paper
Homework must be handed in at the beginning of the class. In your homework solutions, you must use graph paper or PC for plots. You must attach your original plots. Penalties will be given for missing units. Homework must be stapled before submission. Details are required. Late submissions incur a penalty of 20% per day with a 10% minimum. The term paper for graduate students must be typed and spell-checked. The length is 10-15 double-spaced pages not counting the reference list and figures. A typical term paper is much like a literature review article with a focused subject. The report is due at the beginning of the last lecture. 

 

The intended learning outcomes or objectives upon successful completion of the class: Learn the basic principles of biochemical engineering and calculations in enzyme kinetics, cell growth and bioreactor design.

Policy on plagiarism
You may discuss homework problems with your classmates. However, plagiarism is strictly prohibited according to relevant OU regulations. Cheatings on assignments, quizzes and exams may result in a grade of F in the course. For more information please check out the section entitled "Academic Misconduct" in the Ohio University Student Handbook.